Worse Prostate Cancer Outcomes With 5-Alpha-Reductase Inhibitors

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The management of clinically localized prostate cancer that is detected on the basis of prostate-specific antigen (PSA) levels remains controversial. In the United States alone, an estimated 180,89.

NEW YORK (Reuters Health) – Treatment with 5-alpha-reductase inhibitors (5-ARIs) is associated with shorter time to diagnosis and worse mortality in prostate cancer, according to findings from Veterans Affairs electronic health records. "5-ARIs like finasteride and dutasteride reduce the PSA by about 50%," Dr. Brent S. Rose, from the University of California, San Diego in.

A new study looked at health records from around 55,000 UK men who had been prescribed 5-alpha-reductase inhibitors over an 11-year period. Laura James, head of clinical services at Prostate Cancer.

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5 alpha reductase inhibitors e.g. finasteride reduce prostate cancer risk but may increase the risk of high-grade disease in men who are undergoing regular screening for prostate cancer using prostate specific antigen and digital rectal examination

In men with prostate cancer, delayed diagnosis and worse cancer-specific outcomes are linked to prediagnostic use of 5-ARIs. These data highlight an ongoing need to raise awareness of 5-ARI-induced suppression of PSA, set clear guidelines for early detection of prostate cancer, and motivate system-based practices to facilitate optimal care for.

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Furthermore, the new study shows that prostate cancer in men with BRCA2 mutations is associated with worse outcomes and poor responses to. These drugs are PARP inhibitors, which have been approved.

To assess the effects of 5-alpha-reductase inhibitors (5ARIs) for treating lower urinary tract symptoms (LUTS) secondary to benign.. of prostate cancer ( Andriole 2010; Roehrborn 2010).. defined as a worsening of symptoms, increasing prostate volume and decreasing urine flow, having as final outcomes: episodes of.

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The prostate is the gland that produces the fluid that carries sperm.. 5-alpha reductase inhibitors for BPH. TUNA results in better urine flow and relieves BPH symptoms with fewer complications than invasive surgery.